ABSTRACT
To observe the clinical efficacy and safety of bicyclol and polyene phosphatidylcholine in the treatment of liver injury induced by hyperthyroidism. Methods: Totally 112 cases of hyperthyroidism patients were randomly divided into two groups, and both groups were treated with antithyroid drug methimazole. The 56 patients in the treatment group were orally treated with bicyclol, and the other 56 patients in the control group received polyene phosphatidylcholine capsules orally. The changes of liver func-tion were compared before and after the 4-week treatment, including the level of alanine aminotransferase (ALT), aspartate amin-otransferase ( AST) , total bilirubin ( TBIL) and alkaline phosphatase ( ALP) . The efficacy and adverse reactions were also observed. Results:There was no difference in the levels of ALT, AST, TBIL and ALP in both groups before the treatment (P>0. 05), while the levels were all decreased significantly in both groups after the treatment (P0. 05). No drug-related adverse events were shown during the treatment. Conclusion:Bicyclol is effective and reliable in the treatment of liver injury induced by hyperthyroidism, and the clinical efficacy is remarkable when compared with that of polyene phosphatidylcholine.